Day 2 :
Keynote Forum
Maie St John
David Geffen School of Medicine at UCLA
USA
Keynote: An imaging technology for intra-operative surgical margin assessment in oral and head and neck cancers (OSCC)
Biography:
Maie St John is an academic head & neck surgeon with a passion for education. She holds the Pearlman endowed Chair in Otolaryngology/Head and Neck\r\nSurgery and is the Co-Director of the UCLA Head and Neck Cancer Program. The focus of her clinical work is the treatment of head and neck tumors. As chair of\r\nthe Curriculum Committee in the Department of Head and Neck Surgery at UCLA, she developed a critical and comprehensive education program that prepares\r\nour graduates for board certification. Recently, she also received the UCLA Health System Humanism Award, as one of the top 10 most humanistic physicians at\r\nUCLA. She is an active member of several professional societies, including: the American Academy of Otolaryngology-Head and Neck Surgery, the American Head\r\nand Neck Society, the Los Angeles Biomedical Research Institute, the Triological Society and the American Association for Cancer Research.
Abstract:
Oral and Head and neck squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. The primary\r\nmanagement of OSCC relies on complete surgical resection of the tumor. However, the establishment of margin-free\r\nresection is often difficult given the devastating side effects of aggressive surgery and the anatomic proximity to vital structures\r\nsuch as the carotid artery and the spinal cord. Positive margin status is associated with significantly decreased survival. Currently,\r\nit is the surgeon’s fingers that determine where the tumor cuts are made, by palpating the edges of the tumor. Accuracy varies\r\nwidely based on the experience of the surgeon and the location and type of tumor. Efficacy is further confounded by the\r\nrisk of damage to adjacent vital structures, which limit resection margins. The goal of this proposal is to evaluate a novel,\r\nnon-invasive, imaging system based on Dynamic Optical Contrast Imaging (DOCI) that has been developed to differentiate\r\nbetween cancerous and normal tissue intra-operatively using OSCC as the model. The imaging system is based on a novel\r\nrealization of temporally dependent measurements of tissue auto-fluorescence that allow the acquisition of specific tissue\r\nproperties over a large field of view. This system is optimized such that it can be used by surgeons at the time of cancer resection\r\nsurgery to gather quantitative information on margins of malignancies and has been extensively validated in ex vivo OSCC\r\nsamples. Companion histology has verified the sensitivity and specificity of the technique. This intra-operative instrument\r\nwould be the first of its kind, giving us the potential to significantly improve the sensitivity and accuracy of determining true\r\nOSCC margins thus enabling the surgeon to save healthy tissue and improve patient outcomes.
Keynote Forum
Robert Kesmarszky
Budapest University of Technology and Economy
Hungary
Keynote: Otitis externa in tropical areas- A field experience
Biography:
Róbert Késmárszky is currently involved in tropical ENT and Head & Neck surgical projects besides effecting neuro-mechanical research at the University of\r\nTechnology and Economics in Budapest, Hungary. He is passionate about the facial nerve and reconstructive surgery. He is the author of several presentations and\r\nreviewer in the field. Humanitarian work has an important role in his professional activity.
Abstract:
Aim: To analyze the incidence, etiology and characteristics of otitis externa occurring in tropical areas.
\r\nSources & Methods: The anamnestic data, physical examination and documentation were achieved during ENT consultations\r\nto be analyzed retrospectively.
\r\nResults: Otitis externa was a leading motivation to consult in ENT. All age groups and both sexes were included though\r\ndifferences were observed concerning their incidence, cause, side and causative agents. The presence of foreign bodies and\r\nmycosis was higher than experienced in Europe. The presence of mycosis was confirmed clinically when no culture was\r\navailable. Despite of the important pain present in most cases, local cleaning and adapted treatment were usually efficacy.
\r\nConclusion: In tropical areas mycotic otitis externa is more frequent. In many cases aggravated and provocated by the presence\r\nof foreign bodies. Adapted treatment is necessary even when no microbiological confirmation is available. Patient education\r\nis a must.